Depo-Provera Found to Double Risk of Breast Cancer (But Don't Flip Out Just Yet)

Illustration for article titled Depo-Provera Found to Double Risk of Breast Cancer (But Dont Flip Out Just Yet)

Depo-Provera, the injectable contraceptive that's used by roughly 1.2 million women in the U.S., is incredibly convenient, effective, and relatively affordable. But according to a new study, it has a very scary side effect: doubling your risk of breast cancer. But before you freak out because it's coursing (or has ever coursed) through your veins, it might not be as bad as it sounds.

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The study, led by Dr. Christopher Li, who is a breast cancer epidemiologist at the Fred Hutchinson Cancer Research Center, found that, when compared to women who'd never had Depo-Provera shots, women who had used it within the past five years were 2.2. times more likely to have been given a breast cancer diagnosis. They also found that factors like family history, obesity, and age didn't make any difference in their risk being affected.

The increased risk is most likely due to the fact the Depo-Provera contains progestin. It's a synthetic hormone which is also used in Prempro, a hormone pill used to treat postmenopausal women. A previous study found that taking Prempro (which also contains estrogen) increased the risk of breast cancer by a whopping 24 percent. Another hormone therapy pill called Premarin, which has only estrogen and no progestin didn't increase the risk of cancer in any significant way.

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So, because Depo-Provera has this scary-sounding progestin, researchers were not entirely surprised to see a spike in cancer risk. However, similar studies in other countries yielded mixed results, so there's more research to do. But the most important thing to remember, according to Li, is that even though a doubling of risk sounds significant, the main risk factor for breast cancer is age, and so the overall risk for women in their 20s and 30s is still very low. In other words, if your risk is already very low, you can double it, and it's still low.

The other piece is that they found "users' breast cancer risk dropped to that of non-users within several months of stopping Depo-Provera injections," meaning it's possible to bring your risk back down to normal. Still, as Li points out, "there are numerous contraceptive options, and so further clarifying the benefits and risks associated with each option is important as women consider what choices might be best for them." So, for instance, if you're a person who spends a great deal of time fretting over every twinge in your body, worrying that it's a sign of cancer or flesh-eating bacteria, you might want to consider switching to a contraceptive method with fewer risks. But probably you'll be fine, cancer-wise anyway. That flesh-eating bacteria can strike at any time for any reason...

Birth control shots tied to breast cancer risk, study says [MSNBC]

Image via Kamira/Shutterstock.

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DISCUSSION

I recall when depo got popular, all the PA's and docs were calling it "bitch liquid" referring to the mood swings and sometimes drastic weight gain that women would experience.

The link to breast cancer is unsurprising as progestin is a synthetic form of our natural progesterone. Progesterone is necessary for endometrial lining and proper ovulation, but what most people do not know is that progesterone is also a precursor hormone to other hormones which provide other functions. The "side effects" of natural progesterone are generally very good such as aiding in lipolysis, bone building, and keeping O2 sats high at the cellular level. Likely, and this is just me guessing, the synthetic progestin does not act as a precursor and you receive none of the good benefits that you would from your own progesterone. Perhaps the synthetic progestin offsets some of the benefits of natural progesterone as well as creating an imbalance between natural estrogen and progesteron and androgens. I think I will be talking to my doc about this. There are approximately eight different "types" of progestin, and they are used across the contraceptive field.

Edited to correct fucking autocorrect.