I guess you could say he's going Inside Amy Schumer's brain. Or something.
Schumer already wrote the script, but Deadline reports that Apatow is working with her to develop the story and shape it (into something with at least one excellent gross-out bathroom scene in it). He has a history of doing this with already-proven lady talents — please see Bridesmaids and Girls — so here's hoping he allows Schumer to keep her voice intact and that it isn't seventeen hours long. Other than that — godspeed, you comedy emperors.