Wesley's testicles are 160 lbs., six feet in circumference, and growing. While he describes them alternately as giant sacks of potatoes or a "very, very juicy Thanksgiving turkey"—and occasionally will eat dinner (meatballs, naturally) off them—they are not as appetizing as he would make them seem. He's unwilling to admit it, but his balls are the bane of his existence. They are so large that he can't wear pants (he wears hoodies by putting his legs through the arms and sewing up the hood). He has a home health aide named Passion who has to help him perform even the simplest routine tasks. His testicles have grown over his penis—which he admits he hasn't seen in four years—making it difficult to urinate, and although he was featured on last night's episode of the TLC show Strange Sex, he actually cannot have sex, as he can no longer get an erection.
This is all because Wesley suffers from scrotal lymphedemea, in which his lymph channels are obstructed, causing fluid to flow into his testicles, but not flow out. However, this isn't a condition with which he was born. According to Wesley, one of his legs slammed into his scrotum one day four years ago, causing extreme pain. His balls have been growing ever since.
Wesley doesn't want to get surgery because he believes that it might cost about "a million dollars." But he has insurance, so the money excuse doesn't make sense. One doctor, who treated Wesley on the show said their was no reason for his scrotum to have gotten this large, and that it could be corrected with a relatively easy surgery that could be done locally. He even offered to find the surgical team for him. But in the epilogue of the show it says that "Wesley remains hesitant." Perhaps he fears not having something—albeit inhibiting—special about himself. Or maybe he's afraid that he will be able to care for himself after such a surgery and will miss Passion's company.