After losing both her husband and close friend to cancer, Donna Karan has changed her focus from fashion to wellness.

In her efforts to increase the quality of life for patients struggling with illness, she has donated $850,000 to the Beth Israel Medical Center to bring "yoga therapy and a new kind of caregiving" to the cancer wing. At 60, Karan has been practicing yoga for 42 years, and she believes that through yoga and breathing exercises, patients can find the strength to survive. "The nurses and doctors are too busy. We need to think outside the box and find ways to effectively change the medical system," she said. Although this is not the first time Karan has raised money for fighting disease, "this is different," she said. "This is about the optimal caring of the patient and the loved ones." [USA Today]